刘璨,博士,2277.com太阳能集团讲师。2022年毕业于南开大学,获得理学博士学位。
科研领域及方向
[1]复杂天然产物靶点探索
[2]肿瘤药理学
[3]胰腺癌发生发展的作用机制研究。
科研项目情况
[1] 天津市自然科学基金委员会青年项目:以ACT001为分子探针探索olig2调控肺癌干细胞的分子机制,2020-2022,参与
[2] 国家自然科学基金青年项目:抗肝癌干细胞化合物Ovatodiolide的构效关系研究和作用靶点探索,2020-2022,参与
主要学术成果
发表的主要学术论文有:
[1] Liu, C., Wang, L., Sun, Y., Zhao, X., Chen, T., Su, X., Guo, H., Wang, Q., Xi, X., Ding, Y., & Chen, Y. (2022). Probe Synthesis Reveals Eukaryotic Translation Elongation Factor 1 Alpha 1 as the Anti-Pancreatic Cancer Target of BE-43547A2. Angewandte Chemie (International ed. in English), 61(34), e202206953.
[2] Ding, Y., Chen, X., Liu, C., Ge, W., Wang, Q., Hao, X., Wang, M., Chen, Y., & Zhang, Q. (2021). Identification of a small molecule as inducer of ferroptosis and apoptosis through ubiquitination of GPX4 in triple negative breast cancer cells. Journal of hematology & oncology, 14(1), 19.
[3] Li, Y., Liu, Y., Liu, C., Liu, F., Dou, D., Zheng, W., Liu, W., & Liu, F. (2018). Role of a non-canonical splice variant of the Helios gene in the differentiation of acute lymphoblastic leukemic T cells. Oncology letters, 15(5), 6957–6966.
[4] Li, S., Liu, W., Li, Y., Zhao, S., Liu, C., Hu, M., Yue, W., Liu, Y., Wang, Y., Yang, R., Xiang, R., & Liu, F. (2016). Contribution of secondary Igkappa rearrangement to primary immunoglobulin repertoire diversification. Molecular immunology, 78, 193–206.
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