周飒,博士,2277.com太阳能集团副教授,硕士生导师。
主讲课程
本科生:细胞生物学,酿酒作物学,人体微生态与健康调控
研究生:分子药理学,科技论文写作
主要教学研究及成果情况
先后主持校教改项目1项,发表教改论文1篇,参编教材2部。
[1]2022-2023天津科技大学校级教改项目:人体微生态与健康调控“一体两翼三融合”教学体系的构建与实践
[2]参编普通高等教育“十三五规划”教材,植物学, ISBN:9787030616289,2019年8月
[3]参编普通高等学校药学类一流本科专业建设教材,药学分子生物学,ISBN:9787122420015,2023年3月
[4]2022年指导学生获得全国大学生生命科学竞赛三等奖
[5]2022年指导学生获中国大学生酒类创新创意大赛第一名
[6]2021年指导学生获得天津市科普创新竞赛三等奖
[7]指导学生获得天津市生命科学技能竞赛二等奖、三等奖
科研领域及方向
[1]微生物与细胞抗胁迫的机理研究
[2]益生菌对肿瘤细胞和肠道疾病的调控
科研项目情况
[1] 国家自然科学基金项目:CRK41调控微管骨架动态参与响应盐胁迫的作用机制, 3190020293,2020.01-2022.12,主持
[2]国家重点实验室开放基金:根际促生菌Bacillus subtilis NSA18调控H2Bub1响应盐胁迫的作用机制,SKLPPBKF2201, 2022.09-2024.08,主持
[3] 国家重点研发计划子课题,人非细胞生物合成途径设计及超稳人工多酶体系组装,2018YFA0901702,2019.06-2024.06,参与
[4] 国家自然科学基金项目面上项目,组蛋白 H2B 单泛素化调控微管骨架在信号网络核心的时空信号功能及响应盐胁迫的作用机制,31670252,2017.01-2020.12,参与
[5] 国家自然科学基金项目面上项目,组蛋白 H2B 单泛素化参与 Vd-toxins 胁迫应答及调控细胞微管骨架动态的作用机制,31370292,2014.01.01-2017.12.01,参与
主要学术成果
先后发表各类科研论文10余篇,授权发明专利2项。发表的主要学术论文有:
[1] Sa Zhou, Jiamin Xue, Jingbo Shan, Yingxiang Hong, Wenkang Zhu, Zhiyan Nie, Nanxi Ji, Xuegang Luo, Tongcun Zhang, and Wenjian Ma*. Gut-Flora-Dependent Metabolite Trimethylamine-N-Oxide Promotes Atherosclerosis-Associated Inflammation Responses by Indirect ROS Stimulation and Signaling Involving AMPK and SIRT1. 2022, Nutrients 14(16).
[2] Yujie Zhang, Chunyang Ding, Wenkang Zhu, Xinyu Li, Techang Chen, Qingxi Liu, Sa Zhou*, TongCun Zhang*, and Wenjian Ma*. Chemotherapeutic drugs induce oxidative stress associated with DNA repair and metabolism modulation. Life Sciences, 2022, 289:120242.
[3] Sa Zhou, Luo Qiuling, Zhiyan Nie, Changhui Wang, Wenkang Zhu, Yingxiang Hong, Jun Zhao, Baolei Pei, and Wenjian Ma. CRK41 Modulates Microtubule Depolymerization in Response to Salt Stress in Arabidopsis. Plants-Basel, 2023, 12(6):1285.
[4] Sa Zhou, Yupeng Liu, Lijun Jin, Peiyan Guo, Qingxi Liu, Jingbo Shan, Xuegang Luo, Hongpeng He, Wenjian Ma, and TongCun Zhang. Estrogen enhances the cytotoxicity of PARP inhibitors on breast cancer cells through stimulating nitric oxide production. The Journal of Steroid Biochemistry and Molecular Biology, 2021,209:105853.
[5] Sa Zhou, Yuqiao Cai, Xinyi Liu, Lijun Jin, Xiaoqin Wang, Wenjian Ma, and Tongcun Zhang. Role of H2B mono-ubiquitination in the initiation and progression of cancer. Bulletin du Cancer, 2021, 108(4):385-398.
[6] Sa Zhou, Qiuhong Chen, Yuhui Sun, Yingzhang Li. Histone H2B monoubiquitination regulates salt stress-induced microtubule depolymerization in Arabidopsis., Plant, Cell and Environment, 2017, 40: 1512-1530
[7] Sa Zhou, Qiuhong Chen; Xinyue Li; Yingzhang Li ; MAP65-1 is required for the depolymerization and reorganization of cortical, Plant Science, 2017, 254: 112-121
[8] 周飒,单静博,薛佳敏,汪云阳,马文建*. 三甲胺与甲萘醌联用对VSMCs增殖及HUVECs内胆固醇含量的影响. 沈阳药科大学学报,2022,39(1):60-67
[9] Rui Zhang, Qingxi Liu, Sa Zhou, Hongpeng He, Mingfeng Zhao* and Wenjian Ma*, Engineering CAR-NK cells targeting CD33 with concomitant extracellular secretion of anti-CD16 antibody revealed superior antitumor effects toward myeloid leukemia, Cancer Letter 558 (2023): 216103.
[10] Rui Zhang, Qingxi Liu, Sa Zhou, Hongpeng He, Mingfeng Zhao* and Wenjian Ma*. Mesenchymal stem cell suppresses the efficacy of CAR-T toward killing lymphoma cells by modulating the microenvironment through stanniocalcin-1, Elife, 2023, 12.
[11] Jun Zhao, Qiuhong Chen, Sa Zhou, Yuhui Sun, Xinyue Li, Yingzhang Li. H2Bub1 regulates RbohD-dependent H2O2 signal pathway in the defense responses to Verticillium dahliae toxins, Plant Physiology, 2019, 182: 640-657
授权发明专利主要有:
[1] 周飒,张宇洁,马文建等,一种通过 TMAO 研究肠道代谢失衡诱导 AD 的细胞模型,ZL202011070788.5
[2] 周飒,马文建等,毕赤酵母定点 DSB 系统及应用,ZL202011102551.0
联系方式
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Email:zhousa@tust.edu.cn